Designed to help you to put key evidence-based medicine protocols into daily clinical practice. This detailed, yet highly readable reference demystifies the statistical, analytical, and clinical principles of evidence-based medicine, giving you a hands-on, practical resource. Here, you'll learn how to distinguish solid medical evidence from poor medical evidence, devise the best search strategies for each clinical question, critically appraise the medical literature, and optimally tailor evidence-based medicine for each patient. The new second edition of this landmark resource is now completely revised and refreshed throughout, with expanded coverage of both basic and advanced issues in using evidence-based medicine in clinical practice. Current, authoritative content covering how to: avoid being misled by biased presentations of research findings; interpret the significance of clinical trials that are discontinued early; influence clinician behavior to improve patient care; and apply key strategies for teaching evidence-based medicine.